Formulation and Evaluation of Ranitidine Hydrochloride Loaded Floating Microspheres for the Treatment of Gastric Ulcer

The study was aimed to prepare gastro retentive floating microsphere of Ranitidine Hydrochloride by Ionotropic Gelation technique and solvent evaporation using the different carriers’ ratios (Carbopol 934, Chitosan, sodium alginate). Both natural synthetic polymers have been used microspheres evaluated relevant parameters. There no drug carrier interactions assessed from FTIR. Depending upon ratio, percentage yield found between 58.33% 90.38%. in all formulations. surface morphology characterized SEM it discrete, spherical shape with rough outer showed free flowing properties. mean particle size significantly increases increasing polymer concentration range 99.92±1.221 168.23±1.963 µm. Among formulations, RF3 high entrapment efficiency (87.52%). in-vitro buoyancy 66.92% 81.52%. release revealed that RF3, RF6 RF9 Formulations having 89.97%,92.91%,93.68% released at end dissolution studies respectively. It could be concluded developed can for prolonged stomach. Therefore improving bioavailability patient compliance.